Endocrine Abstracts

Introduction: Prolonged QTc interval is a known risk factor for developing ventricular tachyarrhythmias. QTc prolongation is often reported in patients with pheochromocytoma, however the literature data on this issue are rather heterogeneous. Here we report the results of QTc measurement in patients with pheochromocytoma and paraganglioma (PPGL) in comparison to hormonally inactive benign adrenal tumors.Methods: The test group included 204 patients with ...

In 2000 female, 28 y.o., admitted endocrinologist with headache, high blood pressure, dark skin and muscle weakness. Lab data showed high levels of ACTH and cortisol, low potassium level. According to MRI scans, pituitary gland seemed normal. On CT in right adrenal was found 32 mm mass with the native density of 20 HU. Diagnosed ACTH-dependent Cushing syndrome (CS). As Mitotane was not available in Russia at that time, she received ketokonazole due to progression of CS but it ...

Background: The medullary thyroid carcinomas comprise 5-7% of all thyroid carcinomas. At the same time, they are responsible for up to 13% of all deaths of thyroid cancer.Incidence of sporadic medullary thyroid cancer in population 5-6 time higher in women, probably partially because women are likely to have thyroid nodules and undergo medical examination.Objective: The aim of the study is to determine how gender affects prognosis in patient...

Background: It is disputable whether to repeat FNAB after the first one was nondiagnostic, or to submit the patient to operation.Methods: Indication for FNAB was a thyroid nodule of ≥1 cm or of a less size with clinical or ultrasound features of malignancy. In case of multinodular goiter each nodule was punctured and examined separately.3929 cases (8%) were noninformative out of 49 419 FNAB of thyroid nodules performed in Nor...

Background: Fine needle aspiration biopsy is generally acknowledged as a «gold standard» for diagnostics of thyroid malignancies. However, data on FNAB vary considerably in publications from different centers. In this study we have analyzed the results of more than 40 000 FNAB of thyroid nodules performed in North-West Regional Endocrine Center during 2010–2012 years.Subjects and methods: Indication for FNAB was a thyroid nodule of ≥...

Background: Unintented parathyroidectomy during thyroid surgery – is one of typical complications, especially when an operation is augmented by lymphodissection. In this work, we present the results of calcium metabolism analysis in such patients.Subjects and methods: 3929 operations of patients with different thyroid diseases were performed during 2010–2012 years. 82 inadvertently excised parathyroid glands were revealed at histological examin...

Background Undetected multiglandular disease (MGD) is a leading cause of persistent primary hyperparathyroidism after surgical treatment. There is still a number of clinically significant parathyroid adenomas that remain unseen preoperatively.Materials and methods A retrospective cohort study was conducted in order to reveal factors associated with risk of MGD. 810 cases of pHPT patients who had received primary surgical treatment at SPBU Hospital in 201...

Background: Bethesda IV is the most common indication for thyroid surgery. As histological verification is the only 100% certain method of confirming malignancy, surgery remains the gold standard for FN treatment. Most cases of FN malignancy are variants of papillary thyroid cancer that require active surveillance alone in nodules sized less than 2 cm.Materials: A continuous cohort of 4399 patients who underwent surgery at SPbU_Hospital in the years 2020...